Several lines of evidence suggest that the pathobiont Porphyromonas gingivalis is involved in the development and/or progression of auto-inflammatory diseases. This bacterium produces cysteine proteases, such as gingipain RgpA, endowed with the potential to induce significant bone loss in model systems and in patients.
We sought to gain further insight into the role of this pathobiont in rheumatoid arthritis (RA) and to identify novel therapeutic targets for auto-inflammatory diseases.We profiled the antibody response to RgPA-specific domains in patient sera.
Alamar Blue Cell Viability Assay Kit |
|||
K2234-5 | ApexBio | 5ml | EUR 40 |
Description: Cell Biology|Cell Apoptosis |
Alamar Blue Cell Viability Assay Kit |
|||
E37F026-1000tests | EnoGene | 1000 tests | EUR 300 |
Description: Cell proliferation and toxicity test |
Alamar Blue Cell Viability Assay Kit |
|||
E37F026-100tests | EnoGene | 100 tests | EUR 60 |
Description: Cell proliferation and toxicity test |
Alamar Blue Cell Viability Assay Kit |
|||
E37F026-3000tests | EnoGene | 3000 tests | EUR 600 |
Description: Cell proliferation and toxicity test |
Alamar Blue Cell Viability Assay Kit |
|||
E37F026-500tests | EnoGene | 500 tests | EUR 191.67 |
Description: Cell proliferation and toxicity test |
Alamar Blue Cell Viability Assay Kit |
|||
MBS8579843-1000Tests | MyBiosource | 1000Tests | EUR 330 |
Alamar Blue Cell Viability Assay Kit |
|||
MBS8579843-100Tests | MyBiosource | 100Tests | EUR 170 |
Alamar Blue Cell Viability Assay Kit |
|||
MBS8579843-3000Tests | MyBiosource | 3000Tests | EUR 555 |
Alamar Blue Cell Viability Assay Kit |
|||
MBS8579843-500Tests | MyBiosource | 500Tests | EUR 255 |
Alamar Blue Cell Viability Assay Kit |
|||
MBS8579843-5x100Tests | MyBiosource | 5x100Tests | EUR 720 |
Alamar-Blue-Cell-Viability-Assay-Kit |
|||
E37F026 | EnoGene | 1000-tests | EUR 300 |
Description: Cell-proliferation-and-toxicity-test |
QUANTOMTx IQ/OQ Protocol |
|||
LBQ14001 | Westburg | each | EUR 991.9 |
Luna-FL IQ/OQ Protocol |
|||
LBF24003 | Westburg | each | EUR 713.95 |
Mitraphyllin - exact weight protocol |
|||
M374000 | Toronto Research Chemicals | 250mg | EUR 1200 |
Description: 509-80-8 |
Cyflufenamid-d5 - Exact Weight Protocol |
|||
C989602 | Toronto Research Chemicals | 25mg | EUR 12800 |
Antibody column package, 1-step protocol |
|||
An-305P | Creative BioMart | 1 kit | EUR 560 |
Description: Chromatography Reagents |
Antibody column package, 2-step protocol |
|||
An-306P | Creative BioMart | 1 kit | EUR 2032 |
Description: Chromatography Reagents |
His-tagged column package, 2-step protocol |
|||
His-108P | Creative BioMart | 1 kit | EUR 1832 |
Description: Chromatography Reagents |
Luna-II IQ/OQ Protocol and Service - On Location |
|||
LBL44003 | Westburg | each | EUR 1253.5 |
LUNA-FX7 IQ/OQ Protocol (excluding Validation slides) |
|||
LBL74003 | Westburg | each | EUR 1084.55 |
LUNA-FX7 IQ/OQ Package (Protocol, Validation slides BF and FL) |
|||
LBL74004 | Westburg | each | EUR 3068.35 |
Antibody column package, modern Protein A (1-step purification protocol) |
|||
An-002P | Creative BioMart | 1 kit | EUR 560 |
Description: Chromatography Reagents |
Antibody column package, modern Protein A (2-step purification protocol) |
|||
An-003P | Creative BioMart | 1 kit | EUR 2032 |
Description: Chromatography Reagents |
Custom production of antibodies in 1 Goat using supplied antigen (std 63 days protocol) |
|||
GOT-1 | Alpha Diagnostics | 1 | EUR 2252.4 |
Custom production of antibodies in 5 Mice using supplied antigen (std 63 days protocol) |
|||
MIC-5 | Alpha Diagnostics | 1 | EUR 1365.6 |
Custom production of antibodies in 1 Rabbit using supplied antigen (std 63 days protocol) |
|||
RAB-1 | Alpha Diagnostics | 1 | EUR 790.8 |
Custom production of antibodies in 1 Sheep using supplied antigen (std 63 days protocol) |
|||
SHP-1 | Alpha Diagnostics | 1 | EUR 2252.4 |
Custom production of antibodies in 2 Chickens using supplied antigen (std 63 days protocol) |
|||
CHI-2 | Alpha Diagnostics | 1 | EUR 1365.6 |
Custom production of antibodies in 2 Rabbits using supplied antigen (std 63 days protocol) |
|||
RAB-2 | Alpha Diagnostics | 1 | EUR 1365.6 |
Custom production of antibodies in 2 G. Pigs using supplied antigen (std 63 days protocol) |
|||
GPI-2 | Alpha Diagnostics | 1 | EUR 1365.6 |
cAMP Biotrak(TM) EIA; (Non-Acetylation Protocol; Lysis Reagents not Included); Cytiva; RPN2251 - EACH |
|||
GERPN2251 | Scientific Laboratory Supplies | EACH | EUR 770.85 |
Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
|||
RAT-5 | Alpha Diagnostics | 1 | EUR 1365.6 |
alamarBlue |
|||
MBS238967-25mL | MyBiosource | 25mL | EUR 300 |
alamarBlue |
|||
MBS238967-5x25mL | MyBiosource | 5x25mL | EUR 1170 |
AlamarBlue Cell Viability Assay Reagent |
|||
AR4002-10ml | BosterBio | 10ml | EUR 184.8 |
AlamarBlue Cell Viability Assay Reagent |
|||
AR4002-25ml | BosterBio | 25ml | EUR 338.4 |
AlamarBlue Cell Viability Assay Reagent |
|||
AR4002 | BosterBio | 10ml | EUR 90 |
OOSA11224-25ML - alamarBlue Accessory Reagent |
|||
OOSA11224-25ML | Aviva Systems Biology | 25ml | EUR 279 |
OOSA11225-100ML - alamarBlue Accessory Reagent |
|||
OOSA11225-100ML | Aviva Systems Biology | 100ml | EUR 659 |
1L ProtoStain Blue - 1L |
|||
NAT1112 | Scientific Laboratory Supplies | 1L | EUR 174.79 |
Sudan Blue II;Oil Blue 35 |
|||
S688913 | Toronto Research Chemicals | 1g | EUR 92 |
Description: 17354-14-2 |
QUICK BLUE PROTEIN STAIN |
|||
IB01034 | IBI Scientific | 1L | EUR 167.63 |
ECOS Blue (XL1-Blue |
|||
FYE107-10VL | Yeastern Biotech | 100 µl x 10 vials | Ask for price |
ECOS Blue (XL1-Blue |
|||
FYE107-80VL | Yeastern Biotech | 100 µl x 10 vials | Ask for price |
ECOS Blue (XL1-Blue |
|||
FYE108-10VL | Yeastern Biotech | 100 µl x 10 vials | Ask for price |
ECOS Blue (XL1-Blue |
|||
FYE108-80VL | Yeastern Biotech | 100 µl x 10 vials | Ask for price |
ECOS Blue (XL1-Blue |
|||
FYE109-10VL | Yeastern Biotech | 100 µl x 10 vials | Ask for price |
ECOS Blue (XL1-Blue |
|||
FYE109-80VL | Yeastern Biotech | 100 µl x 10 vials | Ask for price |
Aniline Blue (water soluble) (Methyl Blue) |
|||
83344 | Sisco Laboratories | 25 Gms | EUR 4.79 |
Description: Part A |
Luxol Fast Blue ARN (Solvent Blue 37) |
|||
L05250 | Pfaltz & Bauer | 25G | EUR 377.63 |
X-Press Blue Protein Stain |
|||
ML091-500ML | EWC Diagnostics | 1 unit | EUR 53.49 |
Description: X-Press Blue Protein Stain |
Navy Blue 018112 |
|||
N926250 | Toronto Research Chemicals | 50mg | EUR 7600 |
Description: 118685-33-9 |
Basic Blue 7100 |
|||
B118738 | Toronto Research Chemicals | 1g | EUR 109 |
Description: 2390-60-5 |
ProSignal® Blue Protein Stain |
|||
97-101 | Genesee Scientific | 1L/Unit | EUR 202.37 |
Description: SDS-PAGE Coomassie Gel Stain |
Dextran blue 2000 |
|||
20-abx082076 | Abbexa |
|
|
Reactive Blue 19 (Remazol Brilliant Blue R) |
|||
36474 | Sisco Laboratories | 25 Gms | EUR 18.68 |
Description: Part B |
Blink Blue Protein Stain Solution |
|||
TBS5055-100ML | Tribioscience | 100 mL | EUR 89 |
Acid Blue 120 |
|||
T19878-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Acid Blue 120 |
Acid Blue 120 |
|||
T19878-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Acid Blue 120 |
Acid Blue 120 |
|||
T19878-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Acid Blue 120 |
Acid Blue 120 |
|||
T19878-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Acid Blue 120 |
Acid Blue 120 |
|||
T19878-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Acid Blue 120 |
Blue Gal |
|||
21530091-1 | Glycomatrix | 500 mg | EUR 114.99 |
Blue Gal |
|||
21530091-2 | Glycomatrix | 1 g | EUR 184.61 |
Blue Gal |
|||
21530091-3 | Glycomatrix | 100 mg | EUR 59.09 |
Azo blue |
|||
RM10057-5G | EWC Diagnostics | 1 unit | EUR 148.26 |
Description: Azo blue |
Snap Cap 11mm Blue Si/ PTFE Blue - PK1000 |
|||
CHR3550 | Scientific Laboratory Supplies | PK1000 | EUR 1460.7 |
Snap Cap 11mm Blue Si/PTFE Blue - PK1000 |
|||
CHR3552 | Scientific Laboratory Supplies | PK1000 | EUR 631.8 |
Fast Blue |
|||
17740-1 | Polysciences Europe GmbH | 1mg | EUR 160 |
Description: 74749-42-1 |
Fast Blue |
|||
17740-5 | Polysciences Europe GmbH | 5mg | EUR 452 |
Description: 74749-42-1 |
True Blue |
|||
574277 | MedKoo Biosciences | 5.0mg | EUR 595 |
Blue Agar |
|||
M401-500G | EWC Diagnostics | 1 unit | EUR 46.58 |
Description: Blue Agar |
True Blue |
|||
T37667-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: True Blue |
True Blue |
|||
T37667-1g | TargetMol Chemicals | 1g | Ask for price |
Description: True Blue |
True Blue |
|||
T37667-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: True Blue |
True Blue |
|||
T37667-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: True Blue |
True Blue |
|||
T37667-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: True Blue |
True Blue |
|||
MBS5798505-5mg | MyBiosource | 5(mg | EUR 635 |
True Blue |
|||
MBS5798505-5x5mg | MyBiosource | 5x5(mg | EUR 2705 |
Solvent Blue 104 |
|||
S676743 | Toronto Research Chemicals | 10g | EUR 64 |
Description: 116-75-6 |
Albumin blue 670 |
|||
T29837-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Albumin blue 670 |
Albumin blue 670 |
|||
T29837-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Albumin blue 670 |
Albumin blue 670 |
|||
T29837-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Albumin blue 670 |
Albumin blue 670 |
|||
T29837-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Albumin blue 670 |
Albumin blue 670 |
|||
T29837-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Albumin blue 670 |
Albumin blue 670 |
|||
MBS5779469-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Evans Blue |
|||
20-abx082082 | Abbexa |
|
|
Evans Blue |
|||
20-abx082237 | Abbexa |
|
|
Janus blue |
|||
596109 | MedKoo Biosciences | 25.0g | EUR 320 |
Astra Blue |
|||
A790153 | Toronto Research Chemicals | 5g | EUR 3000 |
Evans Blue |
|||
09158-74 | NACALAI TESQUE | 5G | EUR 34.3 |
Evans Blue |
|||
40140055-1 | Glycomatrix | 10 g | EUR 37.07 |
Evans Blue |
|||
abx186080-125g | Abbexa | 125g | EUR 543.6 |
EVANS BLUE |
|||
E2799 | PhytoTechnology Laboratories | 100G | EUR 69.82 |
Night blue |
|||
GRM2345-10G | EWC Diagnostics | 1 unit | EUR 55 |
Description: Night blue |
BLUE-GAL |
|||
X884 | PhytoTechnology Laboratories | 100MG | EUR 114.96 |
Evans Blue |
|||
46650 | Sisco Laboratories | 10 Gms | EUR 12.68 |
Description: Part B |
Astra Blue |
|||
GT8099 | Glentham Life Sciences | 5g | EUR 108.65 |
Evans Blue |
|||
HY-B1102 | MedChemExpress | 100mg | EUR 142.8 |
Astra Blue |
|||
GT8099-25 | Glentham Life Sciences | 25 | EUR 118.7 |
Astra Blue |
|||
GT8099-5 | Glentham Life Sciences | 5 | EUR 31.7 |
Owens Blue |
|||
O03540 | Pfaltz & Bauer | 5G | EUR 211.74 |
Janus blue |
|||
T32263-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Janus blue |
Janus blue |
|||
T32263-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Janus blue |
Janus blue |
|||
T32263-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Janus blue |
Janus blue |
|||
T32263-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Janus blue |
Janus blue |
|||
T32263-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Janus blue |
Evans blue |
|||
T0313-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Evans blue |
Evans blue |
|||
T0313-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Evans blue |
Evans blue |
|||
T0313-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Evans blue |
Evans blue |
|||
T0313-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Evans blue |
Evans blue |
|||
T0313-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Evans blue |
Evans Blue |
|||
abx082082-100l | Abbexa | 100 µl | EUR 125 |
Evans Blue |
|||
abx082082-1ml | Abbexa | 1 ml | Ask for price |
Evans Blue |
|||
abx082082-200l | Abbexa | 200 µl | EUR 162.5 |
Evans Blue |
|||
abx082237-100l | Abbexa | 100 µl | EUR 362.5 |
Evans Blue |
|||
abx082237-1ml | Abbexa | 1 ml | Ask for price |
Evans Blue |
|||
abx082237-200l | Abbexa | 200 µl | Ask for price |
Janus blue |
|||
MBS5781840-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Evans blue |
|||
MBS3604012-100mg | MyBiosource | 100mg | EUR 200 |
Evans blue |
|||
MBS3604012-200mg | MyBiosource | 200mg | EUR 225 |
Evans blue |
|||
MBS3604012-5x200mg | MyBiosource | 5x200mg | EUR 700 |
Evans blue |
|||
MBS575572-100mg | MyBiosource | 100mg | EUR 145 |
Evans blue |
|||
MBS575572-200mg | MyBiosource | 200mg | EUR 165 |
Evans blue |
|||
MBS575572-25mg | MyBiosource | 25mg | EUR 120 |
Evans blue |
|||
MBS575572-50mg | MyBiosource | 50mg | EUR 135 |
Evans blue |
|||
MBS575572-5x200mg | MyBiosource | 5x200mg | EUR 585 |
Disperse Blue 106 |
|||
D493470 | Toronto Research Chemicals | 10mg | EUR 626 |
Description: 68516-81-4 |
Disperse Blue 102 |
|||
D493480 | Toronto Research Chemicals | 500mg | EUR 249 |
Disperse Blue 124 |
|||
D493505 | Toronto Research Chemicals | 100mg | EUR 201 |
Description: 15141-18-1 |
Disperse Blue 291 |
|||
D495358 | Toronto Research Chemicals | 500mg | EUR 1200 |
Description: 56548-64-2 |
Disperse Blue 148 |
|||
HY-D0569 | MedChemExpress | 10mM/1mL | EUR 206.4 |
Disperse Blue 148 |
|||
T18980-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Disperse Blue 148 |
Disperse Blue 148 |
|||
T18980-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Disperse Blue 148 |
Disperse Blue 148 |
|||
T18980-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Disperse Blue 148 |
Disperse Blue 148 |
|||
T18980-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Disperse Blue 148 |
Disperse Blue 148 |
|||
T18980-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Disperse Blue 148 |
Disperse Blue 148 |
|||
MBS5755831-100mg | MyBiosource | 100mg | EUR 160 |
Disperse Blue 148 |
|||
MBS5755831-5x100mg | MyBiosource | 5x100mg | EUR 565 |
Trypan Blue |
|||
20-abx082476 | Abbexa |
|
|
ALCIAN BLUE |
|||
A1286 | PhytoTechnology Laboratories | 100G | EUR 92.65 |
Alcian Blue |
|||
21770003-1 | Glycomatrix | 50 g | EUR 223.05 |
Alcian Blue |
|||
21770003-2 | Glycomatrix | 100 g | EUR 413.84 |
Thymol Blue |
|||
33908-52 | NACALAI TESQUE | 25G | EUR 45.5 |
Thymol Blue |
|||
33908-81 | NACALAI TESQUE | 1G | EUR 21 |
Thymol blue |
|||
464075 | MedKoo Biosciences | 10.0mg | Ask for price |
Trypan Blue |
|||
40140044-1 | Glycomatrix | 25 g | EUR 22.88 |
Trypan Blue |
|||
40140044-2 | Glycomatrix | 100 g | EUR 66.8 |
Thymol Blue |
|||
42040000-1 | Glycomatrix | 5 g | EUR 24.71 |
Thymol Blue |
|||
42040000-2 | Glycomatrix | 25 g | EUR 71.38 |
Thymol Blue |
|||
42040000-3 | Glycomatrix | 100 g | EUR 173.86 |
Blue colour |
|||
PCT1314-250G | EWC Diagnostics | 1 unit | EUR 60.87 |
Description: Blue colour |
Thymol Blue |
|||
27179 | Sisco Laboratories | 5 Gms | EUR 1.51 |
Description: Part A |
Alcian Blue |
|||
48261 | Sisco Laboratories | 5 Gms | EUR 14.7 |
Description: Part B |
Trypan Blue |
|||
58026 | Sisco Laboratories | 25 Gms | EUR 7.95 |
Description: Part B |
Thymol Blue |
|||
GT9755 | Glentham Life Sciences | 5g | EUR 108.65 |
Thymol Blue |
|||
GT9755-10 | Glentham Life Sciences | 10 | EUR 19.8 |
Thymol Blue |
|||
GT9755-100 | Glentham Life Sciences | 100 | EUR 118.7 |
Thymol Blue |
|||
GT9755-100G | Glentham Life Sciences | 100 g | EUR 180 |
Thymol Blue |
|||
GT9755-10G | Glentham Life Sciences | 10 g | EUR 60 |
Thymol Blue |
|||
GT9755-25 | Glentham Life Sciences | 25 | EUR 39.4 |
Thymol Blue |
|||
GT9755-25G | Glentham Life Sciences | 25 g | EUR 84 |
Thymol Blue |
|||
GT9755-5 | Glentham Life Sciences | 5 | EUR 13 |
Thymol Blue |
|||
GT9755-50 | Glentham Life Sciences | 50 | EUR 63.3 |
Thymol Blue |
|||
GT9755-50G | Glentham Life Sciences | 50 g | EUR 112.8 |
Thymol Blue |
|||
GT9755-5G | Glentham Life Sciences | 5 g | EUR 50.4 |
Phenol Blue |
|||
P06900 | Pfaltz & Bauer | 1G | EUR 314.21 |
Alcian blue |
|||
T29840-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Alcian blue |
Alcian blue |
|||
T29840-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Alcian blue |
Alcian blue |
|||
T29840-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Alcian blue |
Alcian blue |
|||
T29840-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Alcian blue |
Alcian blue |
|||
T29840-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Alcian blue |
Methyl Blue |
|||
T19027-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Methyl Blue |
Methyl Blue |
|||
T19027-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Methyl Blue |
Methyl Blue |
|||
T19027-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Methyl Blue |
We also tested the potential protective effects of RgpA domains in an experimental arthritis model.Pre-immunization of rats with purified recombinant RgpA domains alleviated arthritis in the joints of the rodents and reduced bone erosion.
Using a functional genomics approach at both the mRNA and protein levels, we report that the pre-immunizations reduced arthritis severity by impacting a matrix metalloprotease characteristic of articular injury, a chemokine known to be involved in recruiting inflammatory cells, and three inflammatory cytokines.