Gout is an inflammatory arthritis brought on by monosodium urate monohydrate (MSU) crystals’ joint deposition. MSU phagocytosis by resident macrophages is a key step in gout pathogenesis. MSU phagocytosis triggers nuclear issue kappa B (NFκB) activation and manufacturing of cytokines and chemokines. Proteoglycan-4 (PRG4) is a glycoprotein produced by synovial fibroblasts and exerts an anti-inflammatory impact within the joint mediated by its interplay with cell floor receptor CD44. PRG4 additionally binds and antagonizes TLR2 and TLR4. The target of this research is to guage the efficacy of recombinant human PRG4 (rhPRG4) in suppressing MSU-induced irritation and mechanical allodynia in vitro and in vivo.
THP-1 macrophages have been incubated with MSU crystals ± rhPRG4 or bovine submaxillary mucin (BSM), and crystal phagocytosis, cytokines and chemokines expression and manufacturing have been decided. NFκB p65 subunit nuclear translocation, NLRP3 induction, caspase-1 activation and conversion of proIL-1β to mature IL-1β have been studied. MSU phagocytosis by Prg4+/+ and Prg4-/- peritoneal macrophages was decided within the absence or presence of rhPRG4, BSM, anti-CD44, anti-TLR2, anti-TLR4 and isotype management antibodies. Rhodamine-labeled rhPRG4 was incubated with murine macrophages and receptor colocalization research have been carried out. Lewis rats underwent intra-articular injection of MSU crystals adopted by intra-articular therapy with PBS or rhPRG4. Weight bearing and SF myeloperoxidase actions have been decided.
rhPRG4 decreased MSU crystal phagocytosis at Four h (p < 0.01) and IL-1β, TNF-α, IL-Eight and MCP-1 expression and manufacturing at 6 h (p < 0.05). BSM didn’t alter MSU phagocytosis or IL-1β manufacturing in human and murine macrophages. rhPRG4 therapy decreased NFκB nuclear translocation, NLRP3 expression, caspase-1 activation and era of mature IL-1β (p < 0.05). MSU-stimulated IL-1β manufacturing was greater in Prg4-/- macrophages in comparison with Prg4+/+ macrophages (p < 0.001). rhPRG4, anti-CD44, anti-TLR2 and anti-TLR4 antibody therapies decreased MSU phagocytosis and IL-1β manufacturing in murine macrophages (p < 0.05). rhPRG4 preferentially colocalized with CD44 on Prg4-/- peritoneal macrophages in comparison with TLR2 or TLR4 (p < 0.01). rhPRG4 normalized weight bearing and decreased SF myeloperoxidase exercise in comparison with PBS in vivo. rhPRG4 inhibits MSU crystal phagocytosis and reveals an anti-inflammatory and anti-nociceptive exercise in vitro and in vivo. rhPRG4’s anti-inflammatory mechanism could also be as a result of focusing on CD44 on macrophages.
Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing excessive mobility group field 1 and inflammatory cytokines.
Recombinant thrombomodulin (rTM) has pleiotrophic properties, together with anti-coagulation and anti-inflammation; nonetheless, its effectiveness as a therapy for a number of sclerosis (MS) has not been evaluated totally. Excessive mobility group field 1 (HMGB1) and proinflammatory cytokines, working as inflammatory mediators, are reportedly concerned within the inflammatory pathogenesis of MS. The purpose of this research was to find out whether or not rTM generally is a potential therapeutic agent for experimental autoimmune encephalomyelitis (EAE). EAE mice obtained rTM therapy (1 mg or 0·1 mg/kg/day) from days 11 to 15 after immunization.
The scientific variables, plasma ranges of inflammatory cytokines and HMGB1 and pathological findings in EAE have been evaluated. rTM administration ameliorated the scientific and pathological severity of EAE. An immunohistochemical research of the spinal wire confirmed weaker cytoplasmic HMGB1 staining within the rTM-treated EAE mice than within the untreated EAE mice. Plasma ranges of inflammatory cytokines and HMGB1 have been suppressed by rTM therapy. In conclusion, rTM down-regulated inflammatory mediators within the peripheral circulation and prevented HMGB1 launch from nuclei within the central nervous system, suppressing EAE-related irritation. rTM may have a novel therapeutic potential for sufferers with MS.
IL-35 recombinant protein reverses inflammatory bowel illness and psoriasis by means of regulation of inflammatory cytokines and immune cells.
Interleukin-35 (IL-35), a member of the IL-12 household, features as a brand new anti-inflammatory issue concerned in arthritis, psoriasis, inflammatory bowel illness (IBD) and different immune ailments. Though IL-35 can considerably stop the event of irritation in lots of ailments, there have been no early research accounting for the function of IL-35 recombinant protein in IBD and psoriasis. On this research, we assessed the therapeutic potential of IL-35 recombinant protein in three well-known mouse fashions: the dextransulfate sodium (DSS)-induced colitis mouse mannequin, the keratin14 (Okay14)-vascular endothelial development issue A (VEGF-A)-transgenic (Tg) psoriasis mouse mannequin and the imiquimod (IMQ)-induced psoriasis mouse mannequin. Our outcomes indicated that IL-35 recombinant protein can decelerate the pathologic course of in DSS-induced acute colitis mouse mannequin by lowering the infiltrations of macrophages, CD4+ T and CD8+ T cells and by selling the infiltration of Treg cells.
Caspase-2 Fluorometric Assay Kit - 100 assays |
GWB-AXR048 |
GenWay Biotech |
100 assays |
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Caspase-9 Fluorometric Assay Kit - 100 assays |
GWB-AXR056 |
GenWay Biotech |
100 assays |
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Caspase-5 Fluorometric Assay Kit - 100 assays |
GWB-AXR066 |
GenWay Biotech |
100 assays |
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Caspase-4 Fluorometric Assay Kit - 100 assays |
GWB-AXR083 |
GenWay Biotech |
100 assays |
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Caspase-4 Fluorometric Assay Kit - 100 assays |
GWB-AXR084 |
GenWay Biotech |
100 assays |
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Caspase-10 Fluorometric Assay Kit - 100 assays |
GWB-AXR074 |
GenWay Biotech |
100 assays |
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NADH Fluorometric Assay Kit |
K2037-100 |
ApexBio |
100 assays |
EUR 557 |
Description: Detects NADH, highly sensitive. |
Caspase-3 Fluorometric Assay Kit - 200 assays |
GWB-AXR014 |
GenWay Biotech |
200 assays |
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Caspase-3 Fluorometric Assay Kit - 400 assays |
GWB-AXR016 |
GenWay Biotech |
400 assays |
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Caspase-1 Fluorometric Assay Kit - 200 assays |
GWB-AXR025 |
GenWay Biotech |
200 assays |
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Caspase-1 Fluorometric Assay Kit - 400 assays |
GWB-AXR027 |
GenWay Biotech |
400 assays |
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Caspase-8 Fluorometric Assay Kit - 200 assays |
GWB-AXR033 |
GenWay Biotech |
200 assays |
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Caspase-8 Fluorometric Assay Kit - 400 assays |
GWB-AXR035 |
GenWay Biotech |
400 assays |
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Caspase-6 Fluorometric Assay Kit - 200 assays |
GWB-AXR041 |
GenWay Biotech |
200 assays |
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Caspase-6 Fluorometric Assay Kit - 400 assays |
GWB-AXR043 |
GenWay Biotech |
400 assays |
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Caspase-2 Fluorometric Assay Kit - 200 assays |
GWB-AXR049 |
GenWay Biotech |
200 assays |
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Caspase-2 Fluorometric Assay Kit - 400 assays |
GWB-AXR051 |
GenWay Biotech |
400 assays |
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Caspase-9 Fluorometric Assay Kit - 200 assays |
GWB-AXR057 |
GenWay Biotech |
200 assays |
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Caspase-9 Fluorometric Assay Kit - 400 assays |
GWB-AXR059 |
GenWay Biotech |
400 assays |
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Caspase-5 Fluorometric Assay Kit - 200 assays |
GWB-AXR067 |
GenWay Biotech |
200 assays |
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Caspase-5 Fluorometric Assay Kit - 400 assays |
GWB-AXR069 |
GenWay Biotech |
400 assays |
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Caspase-4 Fluorometric Assay Kit - 400 assays |
GWB-AXR082 |
GenWay Biotech |
400 assays |
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Caspase-10 Fluorometric Assay Kit - 200 assays |
GWB-AXR075 |
GenWay Biotech |
200 assays |
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Caspase-10 Fluorometric Assay Kit - 400 assays |
GWB-AXR077 |
GenWay Biotech |
400 assays |
Ask for price |
GWB-AXR013-100T - Caspase-3 Fluorometric Assay Kit - 100 assays |
GWB-AXR013-100T |
Aviva Systems Biology |
100assays |
EUR 629 |
|
Caspase-3 Fluorometric Assay Kit - 25 assays |
GWB-AXR015 |
GenWay Biotech |
25 assays |
Ask for price |
Caspase-1 Fluorometric Assay Kit - 25 assays |
GWB-AXR026 |
GenWay Biotech |
25 assays |
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Caspase-8 Fluorometric Assay Kit - 25 assays |
GWB-AXR034 |
GenWay Biotech |
25 assays |
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Caspase-6 Fluorometric Assay Kit - 25 assays |
GWB-AXR042 |
GenWay Biotech |
25 assays |
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Caspase-2 Fluorometric Assay Kit - 25 assays |
GWB-AXR050 |
GenWay Biotech |
25 assays |
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Caspase-9 Fluorometric Assay Kit - 25 assays |
GWB-AXR058 |
GenWay Biotech |
25 assays |
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Caspase-5 Fluorometric Assay Kit - 25 assays |
GWB-AXR068 |
GenWay Biotech |
25 assays |
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Caspase-4 Fluorometric Assay Kit - 25 assays |
GWB-AXR085 |
GenWay Biotech |
25 assays |
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Caspase-10 Fluorometric Assay Kit - 25 assays |
GWB-AXR076 |
GenWay Biotech |
25 assays |
Ask for price |
PicoProbe? NADH Fluorometric Assay Kit |
K338-100 |
Biovision |
each |
EUR 692.4 |
NAD+/NADH Assay Kit (Fluorometric) |
MET-5030 |
Cell Biolabs |
100 assays |
EUR 495 |
NAD+/NADH Assay Kit (Fluorometric) |
MBS169286-100Assays |
MyBiosource |
100Assays |
EUR 680 |
NAD+/NADH Assay Kit (Fluorometric) |
MBS169286-5x100Assays |
MyBiosource |
5x100Assays |
EUR 3120 |
Caspase-3 DEVD-R110 Fluorometric and Colorimetric Assay Kit (100 assays) |
30008-2 |
Biotium |
1KIT |
EUR 459.6 |
Description: Minimum order quantity: 1 unit of 1KIT |
Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (100 assays) |
30011-2 |
Biotium |
1KIT |
EUR 459.6 |
Description: Minimum order quantity: 1 unit of 1KIT |
Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (25 assays) |
30011-1 |
Biotium |
1KIT |
EUR 244.8 |
Description: Minimum order quantity: 1 unit of 1KIT |
GST Fluorometric Assay Kit |
55R-1350 |
Fitzgerald |
100 assays |
EUR 513 |
|
Description: Assay Kit for detection of GST activity in the research laboratory |
HDAC Fluorometric Assay kit |
TBS2060 |
Tribioscience |
100 tests |
EUR 289 |
NADP+/NADPH Assay Kit (Fluorometric) |
MET-5031 |
Cell Biolabs |
100 assays |
EUR 495 |
NADP+/NADPH Assay Kit (Fluorometric) |
MBS169287-100Assays |
MyBiosource |
100Assays |
EUR 680 |
NADP+/NADPH Assay Kit (Fluorometric) |
MBS169287-5x100Assays |
MyBiosource |
5x100Assays |
EUR 3120 |
Glucose Fluorometric Assay Kit |
K2221-100 |
ApexBio |
100 assays |
EUR 571 |
Description: Detects glucose, highly sensitive, high throughput screening (HTS). |
Lactate Fluorometric Assay Kit |
K2140-100 |
ApexBio |
100 assays |
EUR 586 |
Description: Detects lactate, highly sensitive, high throughput screening (HTS). |
Inosine Fluorometric Assay Kit |
K712-100 |
Biovision |
each |
EUR 639.6 |
Ethanol Fluorometric Assay kit |
TBS2095 |
Tribioscience |
100 tests |
EUR 259 |
Sucrose Fluorometric Assay Kit |
E-BC-F042-96T |
Elabscience Biotech |
96T |
EUR 350 |
|
Description: Quantitative |
Sucrose Fluorometric Assay Kit |
E-BC-F042-each |
Elabscience Biotech |
each |
Ask for price |
|
Description: Quantitative |
Sucrose Fluorometric Assay Kit |
MBS2567974-5x96Test |
MyBiosource |
5x96Test |
EUR 1770 |
Sucrose Fluorometric Assay Kit |
MBS2567974-5x96Tests |
MyBiosource |
5x96Tests |
EUR 1770 |
Sucrose Fluorometric Assay Kit |
MBS2567974-96Test |
MyBiosource |
96Test |
EUR 390 |
Sucrose Fluorometric Assay Kit |
MBS2567974-96Tests |
MyBiosource |
96Tests |
EUR 390 |
Glycogen Fluorometric Assay Kit |
E-BC-F040-500Assays |
Elabscience Biotech |
500 Assays |
EUR 1000 |
|
Description: Quantitative |
Glycogen Fluorometric Assay Kit |
E-BC-F040-96T |
Elabscience Biotech |
96T |
EUR 425 |
|
Description: Quantitative |
Glycogen Fluorometric Assay Kit |
E-BC-F040-each |
Elabscience Biotech |
each |
Ask for price |
|
Description: Quantitative |
Glycogen Fluorometric Assay Kit |
MBS2567972-500Tests |
MyBiosource |
500Tests |
EUR 910 |
Glycogen Fluorometric Assay Kit |
MBS2567972-5x100Tests |
MyBiosource |
5x100Tests |
EUR 4200 |
Glycogen Fluorometric Assay Kit |
MBS2567972-5x96Test |
MyBiosource |
5x96Test |
EUR 2070 |
Glycogen Fluorometric Assay Kit |
MBS2567972-96Test |
MyBiosource |
96Test |
EUR 455 |
Glycogen Fluorometric Assay Kit |
MBS2567972-96Tests |
MyBiosource |
96Tests |
EUR 455 |
Phosphate Fluorometric Assay Kit |
55R-1404 |
Fitzgerald |
100 assays |
EUR 367 |
|
Description: Assay Kit for detection of Phosphate in the research laboratory |
Phosphate Fluorometric Assay Kit |
GWB-AXR232 |
GenWay Biotech |
100 assays |
Ask for price |
Glutathione Fluorometric Assay Kit |
K2098-100 |
ApexBio |
100 assays |
EUR 595 |
Description: Simple assay to detect total glutathione |
Glutathione Fluorometric Assay Kit |
K251-100 |
Biovision |
each |
EUR 574.8 |
Zinc Assay Kit (Fluorometric) |
K428-100 |
Biovision |
each |
EUR 627.6 |
Triglyceride Fluorometric Assay Kit |
E-BC-F033-48T |
Elabscience Biotech |
48T |
EUR 356 |
|
Description: Quantitative |
Triglyceride Fluorometric Assay Kit |
E-BC-F033-96T |
Elabscience Biotech |
96T |
EUR 520 |
|
Description: Quantitative |
Triglyceride Fluorometric Assay Kit |
E-BC-F033-each |
Elabscience Biotech |
each |
Ask for price |
|
Description: Quantitative |
Adipogenesis Fluorometric Assay Kit |
E-BC-F065-96T |
Elabscience Biotech |
96T |
EUR 350 |
|
Description: Quantitative |
Adipogenesis Fluorometric Assay Kit |
E-BC-F065-each |
Elabscience Biotech |
each |
Ask for price |
|
Description: Quantitative |
Triglyceride Fluorometric Assay Kit |
MBS2571977-48Tests |
MyBiosource |
48Tests |
EUR 390 |
Triglyceride Fluorometric Assay Kit |
MBS2571977-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2435 |
Triglyceride Fluorometric Assay Kit |
MBS2571977-96Test |
MyBiosource |
96Test |
EUR 530 |
Phenylalanine Fluorometric Assay Kit |
K572-100 |
Biovision |
each |
EUR 574.8 |
Caspase 3 Fluorometric Assay Kit |
55R-1269 |
Fitzgerald |
25 assays |
EUR 527 |
|
Description: Assay Kit for detection of Capase 3 activity in the research laboratory |
Caspase 1 Fluorometric Assay Kit |
55R-1272 |
Fitzgerald |
25 assays |
EUR 527 |
|
Description: Assay Kit for detection of Capase 1 activity in the research laboratory |
Caspase 8 Fluorometric Assay Kit |
55R-1274 |
Fitzgerald |
25 assays |
EUR 527 |
|
Description: Assay Kit for detection of Capase 8 activity in the research laboratory |
Caspase 6 Fluorometric Assay Kit |
55R-1276 |
Fitzgerald |
25 assays |
EUR 467 |
|
Description: Assay Kit for detection of Capase 6 activity in the research laboratory |
Caspase 2 Fluorometric Assay Kit |
55R-1278 |
Fitzgerald |
25 assays |
EUR 507 |
|
Description: Assay Kit for detection of Capase 2 activity in the research laboratory |
Caspase 9 Fluorometric Assay Kit |
55R-1280 |
Fitzgerald |
25 assays |
EUR 513 |
|
Description: Assay Kit for detection of Capase 9 activity in the research laboratory |
Caspase 5 Fluorometric Assay Kit |
55R-1282 |
Fitzgerald |
25 assays |
EUR 473 |
|
Description: Assay Kit for detection of Capase 5 activity in the research laboratory |
Caspase 10 Fluorometric Assay Kit |
55R-1284 |
Fitzgerald |
25 assays |
EUR 507 |
|
Description: Assay Kit for detection of Capase 10 activity in the research laboratory |
Caspase 4 Fluorometric Assay Kit |
55R-1286 |
Fitzgerald |
25 assays |
EUR 513 |
|
Description: Assay Kit for detection of Capase 4 activity in the research laboratory |
Starch Assay Kit (Fluorometric) |
MET-5026 |
Cell Biolabs |
100 assays |
EUR 410 |
Malate Assay Kit (Fluorometric) |
MET-5120 |
Cell Biolabs |
100 assays |
EUR 395 |
Lysine Assay Kit (Fluorometric) |
MET-5129 |
Cell Biolabs |
100 assays |
EUR 525 |
Starch Assay Kit (Fluorometric) |
MBS169282-100Assays |
MyBiosource |
100Assays |
EUR 580 |
Starch Assay Kit (Fluorometric) |
MBS169282-5x100Assays |
MyBiosource |
5x100Assays |
EUR 2655 |
Malate Assay Kit (Fluorometric) |
MBS169576-100Assays |
MyBiosource |
100Assays |
EUR 560 |
Malate Assay Kit (Fluorometric) |
MBS169576-5x100Assays |
MyBiosource |
5x100Assays |
EUR 2575 |
Lysine Assay Kit (Fluorometric) |
MBS169586-100Assays |
MyBiosource |
100Assays |
EUR 710 |
Lysine Assay Kit (Fluorometric) |
MBS169586-5x100Assays |
MyBiosource |
5x100Assays |
EUR 3275 |
Caspase-3 Fluorometric Assay Kit |
K2007-100 |
ApexBio |
100 assays |
EUR 322 |
Description: Detects DEVD-dependent caspase activity, highly-sensitive. |
Caspase-3 Fluorometric Assay Kit |
K2007-200 |
ApexBio |
200 assays |
EUR 469 |
Description: Detects DEVD-dependent caspase activity, highly-sensitive. |
Caspase-3 Fluorometric Assay Kit |
K2007-25 |
ApexBio |
25 assays |
EUR 143 |
Description: Detects DEVD-dependent caspase activity, highly-sensitive. |
Caspase-3 Fluorometric Assay Kit |
K2007-400 |
ApexBio |
400 assays |
EUR 789 |
Description: Detects DEVD-dependent caspase activity, highly-sensitive. |
Caspase-1 Fluorometric Assay Kit |
K2010-100 |
ApexBio |
100 assays |
EUR 586 |
Description: Detects YVAD-dependent caspase activity, highly-sensitive. |
Caspase-1 Fluorometric Assay Kit |
K2010-200 |
ApexBio |
200 assays |
EUR 835.2 |
Caspase-1 Fluorometric Assay Kit |
K2010-25 |
ApexBio |
25 assays |
EUR 285.6 |
Caspase-1 Fluorometric Assay Kit |
K2010-400 |
ApexBio |
400 assays |
EUR 1303.2 |
Caspase-8 Fluorometric Assay Kit |
K2012-100 |
ApexBio |
100 assays |
EUR 322 |
Description: Detects IETD-dependent caspase activity, highly-sensitive. |
Caspase-8 Fluorometric Assay Kit |
K2012-200 |
ApexBio |
200 assays |
EUR 492 |
Description: Detects IETD-dependent caspase activity, highly-sensitive. |
Caspase-8 Fluorometric Assay Kit |
K2012-25 |
ApexBio |
25 assays |
EUR 143 |
Description: Detects IETD-dependent caspase activity, highly-sensitive. |
Caspase-8 Fluorometric Assay Kit |
K2012-400 |
ApexBio |
400 assays |
EUR 789 |
Description: Detects IETD-dependent caspase activity, highly-sensitive. |
Caspase-6 Fluorometric Assay Kit |
K2014-100 |
ApexBio |
100 assays |
EUR 322 |
Description: Detects VEID-dependent caspase activity, highly-sensitive. |
Caspase-6 Fluorometric Assay Kit |
K2014-200 |
ApexBio |
200 assays |
EUR 492 |
Description: Detects VEID-dependent caspase activity, highly-sensitive. |
Caspase-6 Fluorometric Assay Kit |
K2014-25 |
ApexBio |
25 assays |
EUR 143 |
Description: Detects VEID-dependent caspase activity, highly-sensitive. |
Caspase-6 Fluorometric Assay Kit |
K2014-400 |
ApexBio |
400 assays |
EUR 789 |
Description: Detects VEID-dependent caspase activity, highly-sensitive. |
Caspase-2 Fluorometric Assay Kit |
K2016-100 |
ApexBio |
100 assays |
EUR 571 |
Description: Detects VDVAD-dependent caspase activity, highly-sensitive. |
Caspase-2 Fluorometric Assay Kit |
K2016-200 |
ApexBio |
200 assays |
EUR 835.2 |
Caspase-2 Fluorometric Assay Kit |
K2016-25 |
ApexBio |
25 assays |
EUR 285.6 |
Caspase-2 Fluorometric Assay Kit |
K2016-400 |
ApexBio |
400 assays |
EUR 1336.8 |
Caspase-9 Fluorometric Assay Kit |
K2018-100 |
ApexBio |
100 assays |
EUR 571 |
Description: Detects LEHD-dependent caspase activity, highly-sensitive. |
Caspase-9 Fluorometric Assay Kit |
K2018-200 |
ApexBio |
200 assays |
EUR 802.8 |
Caspase-9 Fluorometric Assay Kit |
K2018-25 |
ApexBio |
25 assays |
EUR 285.6 |
Caspase-9 Fluorometric Assay Kit |
K2018-400 |
ApexBio |
400 assays |
EUR 1336.8 |
Caspase-3 Fluorometric Assay Kit |
K105-100 |
Biovision |
each |
EUR 574.8 |
Caspase-3 Fluorometric Assay Kit |
K105-200 |
Biovision |
each |
EUR 744 |
Caspase-3 Fluorometric Assay Kit |
K105-25 |
Biovision |
each |
EUR 248.4 |
Caspase-3 Fluorometric Assay Kit |
K105-400 |
Biovision |
each |
EUR 1174.8 |
Caspase-9 Fluorometric Assay Kit |
K118-100 |
Biovision |
each |
EUR 561.6 |
Caspase-9 Fluorometric Assay Kit |
K118-200 |
Biovision |
each |
EUR 738 |
Caspase-9 Fluorometric Assay Kit |
K118-25 |
Biovision |
each |
EUR 248.4 |
Caspase-9 Fluorometric Assay Kit |
K118-400 |
Biovision |
each |
EUR 1149.6 |
Caspase-8 Fluorometric Assay Kit |
K112-100 |
Biovision |
each |
EUR 574.8 |
Caspase-8 Fluorometric Assay Kit |
K112-200 |
Biovision |
each |
EUR 738 |
Caspase-8 Fluorometric Assay Kit |
K112-25 |
Biovision |
each |
EUR 248.4 |
Additional evaluation demonstrated that IL-35 recombinant protein might regulate irritation by means of selling the secretion of IL-10 and inhibiting the expression of pro-inflammatory cytokines similar to IL-6, TNF-α and IL-17 in acute colitis mannequin. As well as, decrease dose of IL-35 recombinant protein may obtain long-term therapy results as TNF-α monoclonal antibody did within the psoriasis mouse. In abstract, the outstanding therapeutic results of IL-35 recombinant protein in acute colitis and psoriasis mouse fashions indicated that IL-35 recombinant protein had a wide range of anti-inflammatory results and was anticipated to develop into an efficient candidate drug for the therapy of inflammatory ailments. Elevated data of the immune response of the gut, a physiologically crucial organ concerned in absorption, secretion and homeostasis in a non-sterile atmosphere, is required to raised perceive the mechanisms concerned within the induction of long-lasting immunity and, subsequently, the event of efficacious gastrointestinal immunization approaches. To this finish, evaluation of remoted intestine cells will give an perception into the cell varieties current and their immune functionality. Therefore, on this research we first optimised a way for salmonid intestine leucocyte isolation and characterised the cells on the premise of their expression of a variety of chosen cell markers related to T & B cells and dendritic cells.